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I have been suffering from psoriasis for more than 5 years and I tried a number of different treatments, but only methotrexate helps. I had psoriasis in my hands, scalp, back, most body parts. It is really difficult sometimes to switch from one medication to another because the effect takes time to reveal and my skin condition may worsen significantly. That's why I'm very happy that I found a trusted medication and don't have to look for anything else.
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I have been taking methotrexate for about 2 years for moderate rheumatoid arthritis (22.5mg weekly) and it does control inflammation. I recently stopped taking it for 3 months because I really don't like taking drugs and symptoms returned (inflammation in ankles, hip pain, stiffness) so I started taking it again and have no pain so obviously it was working.

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What it is: Methotrexate belongs to a class of drugs known as antimetabolites, and it works by interfering with the overproduction of skin cells that causes psoriatic plaques to develop.

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In my opinion, the cost of this kind of therapy is just too great long-term, the disadvantages outweigh the benefits.

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The mechanisms of this phenomenon are uncertain, but the development of these autoantibodies was only rarely associated with symptoms suggestive of an autoimmune disease.

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The DREAM study was not a randomized, controlled clinical trial, since it was based on patient records, so the results are not as robust as they would be if this had been a clinical trial.

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Although a literature review of these data, largely derived from the rheumatoid arthritis literature, suggests that low-dose folate supplementation may reduce the hematologic, gastrointestinal, and hepatic side effects of methotrexate without decreasing the efficacy, 21 one small controlled study in patients with psoriasis using folic acid at 5 mg daily suggested that there may be a slight decrease in efficacy.

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